内皮祖细胞

Endothelial Progenitor Cells

内皮祖细胞参与胚胎期原始血管网的形成。但近年的研究证实,内皮祖细胞参与出生后的内皮修复和血管新生过程,提示内皮祖细胞在血管再生和心血管疾病治疗中具有很好的应用前景。目前,确定内皮祖细胞还没有一个统一的标准,相对认可为内皮祖细胞的是含CD34、CD133、FLK-1等标志的阳性细胞。在正常情况下,外周血中EPC数量很低。本文侧重综述了EPCs的表型、鉴定、分离培养、数量。

during embryogenesis,endothelial progenitor cells participate in the initial processes of primitive blood vessel formation.It becomes evidently that endothelial progenitor cells are involved in postnatal reendothelization and vasculogenesis.It is suggested that endothelial progenitor cells will have clinical application prospects in vascular regeneration and treatment of heart and vascular diseases.Currently,there is no uniform definition of EPC,it was primarily defined by expression of cell surface antigens CD34、CD133、FLK-1.under steady-state physiological condition,quantity of EPCs is very low.In this review,we sum up pareiculary on phenotype,identification,isolation and culture and quantity of EPCs.