青海省2004～2005年麻疹实验室监测结果分析

ANALYSIS OF LABORATORY SURVEILLANCE RESULTS OF MEASLES IN 2004～2005 IN QINGHAI PROVINCE

目的 汇总分析2004～2005年青海省麻疹实验室的监测数据. 方法 用抗体捕捉酶联免疫吸附实验(ELISA)检测. 结果 发病年龄主要在0～15岁;地区主要分布在经济文化相对落后的农牧区;2004年无明显季节高峰,2005年3～6月为发病高峰.14起暴发中,有12起经实验室确诊为麻疹暴发,1起为风疹暴发,1起未确诊.有详细记录的324例标本检测结果表明,出疹后8～14d采集的标本,阳性检出率高;核苷酸同源性分析结果显示我省流行的麻疹野病毒属于H1a基因亚型.结论 应加强农牧地区0～15岁儿童麻疹强化免疫,青海麻疹高发季节滞后于其他地区.

Objective Laboratory surveillance of measles were collected and analysedduring 2004~2005.Methods The IgM antibody of measles is texted by ELISA.Results Their age was between 0~15 years old,mainly distributed in the area of economy and culture relalively undeveloped countrysides and grasslands.The disease peak was no rule in 2004,but the disease peak was from March to June in 2005.12 of the 14 measles outbreak were confirmed as measles,1 of the 14 were rnbella,and the other one outbreak were unidentified.Testing of 324 serum sample indicated that the highest measles positive detection rate was from the serum samples collected at 8~14 days after rash appearance.The sequence analysis of 450 nucleotides of COOH-terminal of nucleoprotein(N) genes of 7 isolates indicated that all of the Qinghai viruses were members of H1 genotype.Conclusion To strengthen the Measles Supplementary Immunization Activies during 0~15 years old.The disease peak of Qinghai measles is later than other area.