氟西汀和阿米替林治疗肠易激综合征的疗效观察

Observation on Effect of Fluoxetine Hydrochloride and Amitriptyline on Treatment of Irritable Bowel Syndrome.

目的:观察氟西汀(百忧解)和阿米替林治疗肠易激综合征(IBS)的疗效及安全性。方法:将102例肠易激综合征病人随机分为三组,常规组31例根据治疗个体化原则给予抗肠易激综合征常规治疗,氟西汀组36例在常规治疗基础上联合应用氟西汀治疗,阿米替林组35例在常规治疗基础上联合应用阿米替林治疗,疗程均为8周。结果:氟西汀组总有效率88.9%,阿米替林组总有效率85.7%,常规组总有效率71.3%。氟西汀组、阿米替林组与常规组分别比较,差异有显著意义(P<0.05),氟西汀组与阿米替林组比较差异无显著意义(P>0.05)。结论:常规治疗肠易激综合征时加用氟西汀、阿米替林疗效更显著,氟西汀不良反应较阿米替林少,安全性高,更适合推广使用。

Objectives:To observe the effect of Fluoxetine Hydrochloride and Amitriptyline on treatment of Irritable bowel syndrome(IBS) and their safety.Methods:We randomly divided 102 cases of IBS into three groups.Thirty-one cases in routine group were treated with individualized routine treatment.Thirty-six cases in Fluoxetine Hydrochloride group were treated with individualized routine treatment and Fluoxetine Hydrochloride.Thirty-five cases in Amitriptyline group were treated with individualized routine treatment and Amitriptyline.The periods of treatment were 8 weeks.Results:The effective rates for the Fluoxetine Hydrochloride group,the Amitriptyline group and the routine group were 88.9%,85.7% and 61.3%,respectively.There were great significant differences between the Fluoxetine Hydrochloride group and the routine group(P<0.05),and between the Amitriptyline group and the routine group(P<0.05).There was not significant difference between the Fluoxetine Hydrochloride group and the Amitriptyline group(P>0.05).Conclusions:Routine treatment combined with Fluoxetine Hydrochloride and Amitriptyline to IBS is more effective,more safety,less side effect and more easily popularized.