γ-干扰素雾化吸入治疗支气管哮喘的临床观察被引量：2

Clinical observation of INF-γ spray inhalation on the treatment of asthma

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摘要目的观察雾化吸入γ-干扰素(INF-γ)对支气管哮喘患者的疗效和安全性。方法66例哮喘患者随机分为对照组(常规治疗)、治疗组(常规治疗加雾化吸入INF-γ),疗程均为14d。详细观察治疗前后患者临床症状、肺功能、肝功能、肾功能、INF-γ水平和嗜酸粒细胞计数的变化。结果治疗组改善临床症状优于对照组,差异有显著性(P<0.05)。与对照组相比,治疗组在肺功能、血清INF-γ、IgE、嗜酸粒细胞水平的作用更明显(P<0.05)。结论雾化吸入INF-γ是一种支气管哮喘安全有效的治疗方法。 [Objective] To observe efficacy and safety of INF-γ spray inhalation on the treatment of asthma. [Methods] Sixty-six patients with asthma were randomly divided into two groups, the INF-γ treatment group (conventional therapy & INF-γ) and the control group (conventional therapy). The treatment course for two groups were both 14 days. Observation units including clinical symptoms, pulmonary function, INF-γ level, IgE level and eosinophils count, were investigated in detail before and after treatment. [Results] The INF-γ treatment group made more improvement on symptom than that of control group with a significant difference (P <0.05). Pulmonary function showed significant difference between two groups after treatment for 14 days, as well as INF-γ level, IgE level and eosinophils count (P <0.05). [Conclusion] INF-γ spray inhalation is an effect and safety asthma treatment method.

作者李宏云冯永海秦超任红梅

机构地区郑州大学第五附属医院呼吸科

出处《中国现代医学杂志》 CAS CSCD 北大核心 2006年第24期3809-3811,共3页 China Journal of Modern Medicine

关键词 Γ-干扰素雾化吸入支气管哮喘 INF-γ spray inhalation asthma

分类号 R562.25 [医药卫生—呼吸系统]

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