壳寡糖对荷瘤鼠免疫功能的影响

Influence of chitosan oligosaccharide on immunity function of tumor mice

目的通过建立H22肝癌荷瘤鼠作为实验动物模型,研究壳寡糖对荷瘤鼠免疫功能的影响。方法选择小鼠体内注射的方法将不同浓度壳寡糖注入荷瘤小鼠体内,观察肿瘤生长情况,对其进行免疫功能的测定。结果壳寡糖可提高荷瘤小鼠血清的IL-2和INF-r含量,增加荷瘤小鼠免疫器官脾脏和胸腺重量。结论壳寡糖可抑制肿瘤生长,提高机体免疫功能。

Objective To experiment the tumor animal model to the H22 Cancer of the liver mice,and study the influence of chitosan oligosaccharide on immunity function of tumor mice.Methods The growth of tumor were observed after different density chitosan oligosaccharide were injected into the mice,then the immunity function were measured.Results Chitosan oligosaccharide can increase the content of IL-2 and INF-ν in the serum and the weight of spleen and thymus of the mice.Conclusions Chitosan oligosaccharide can inhibit the growth of tumor,improve the function of immunity.