期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一种Th1-like调节性T细胞新亚群

下载PDF
导出
摘要 本文描述了一种独特的调节性T细胞亚群——Th1-like调节性T细胞,这类细胞是卵清蛋白特异性的调节性T细胞,经CD8α+DC诱导产生,其表达的表面标志与Th1细胞和调节性T细胞均有相似之处,既表达Th1细胞的特异性标志T-bet,又表达调节性T细胞的特异性标志Foxp3。Th1-like调节性T细胞分泌IL-10、IFN-γ等细胞因子,这些细胞因子在免疫抑制与平衡中发挥重要作用。Th1-like调节性T细胞主要作用于呼吸道,对气道超反应呈现显著抑制作用。
作者 郝文婷 邢飞跃
机构地区 广州暨南大学生命科学技术学院组织移植与免疫中心
出处 《现代免疫学》 CAS CSCD 北大核心 2008年第3期253-256,共4页 Current Immunology
基金 国家自然科学基金资助项目(30471635) 广东省自然科学基金资助项目(04010451 5006033)
关键词 Th1-like调节性T细胞 CD4+CD25+调节性T细胞 Tr1 Th3
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献18

  • 1[1]Stock P,Akbari O,Berry G,et al.Induction of T helper type 1-like.regulatory ceils that express Foxp3 and protect against airway hyper-reactivity[J].Nat Immunol,2004,5(11):1149-1156.
  • 2[2]Stock P,DeKruyff RH,Umetsu DT.Inhibition of the allergic response by regulatory T cells[J].Curr Opin Allergy Clin Immunol,2006,6(1):12-16.
  • 3[3]Akbari O,Stock P,DeKruyff RH,et al.Role of regulatory T cells in allergy and asthma[J].Curr Opin lmmunol,2003,15(6):627-633.
  • 4[4]Boschiero L,Nacchia F,Fior F,et al.Specific alloantigen self-control by regulatory T cells in organ transplantation:A review[J].Transplant Proe,2007,39(6),2013-2017.
  • 5[5]Swirski FK,D'Sa A,Kianpour S,et al.Prolonged ovalburain exposure attenuates airway hyperresponsiveness and T cell function in mice[J].Int Arch Allergy Immunol,2006,141(2):130-140.
  • 6[6]Kim JY,Kim HJ,Hurt EM.Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells[J].Biochem Biophys Res Commun,2007,362(1):44-50.
  • 7[7]Gavin MA,Rasmussen JP.Foxp3 dependent programme of regulatory T-cell differentiation[J].Nature,2007,445(7129):771-775.
  • 8[8]Williams LM,Rudensky AY.Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3[J].Nat Immunol,2007,8(3):277-284.
  • 9[9]Wan YY,Flavell RA.Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression[J].Nature,2007,445(7129):766 770.
  • 10李卫鹏,王福庆.CD4^+CD25^+ Treg的免疫调节作用机制以及临床研究进展[J].现代免疫学,2006,26(2):164-167. 被引量：18

二级参考文献21

  • 1Bruder D, Probst-Kepper M, Westendorf A, et al. Neuropiliin-1: a surface marker of regulatory T cells[J]. Eur J Immunol, 2004,34(3):623-630.
  • 2Fontenot J, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4^+ CD25^+ regulatory T cells[J]. Nat Immunol, 2003,4(4):330-336.
  • 3Nakamura K, Kitani A, Strober W, Cell contact-dependent immunosuppression by CD4^+ CD25^+ regulatory T cells is medialed by cell surface bound transforming growth factor[J]. J Exp Med, 2001,194(5) :629-644.
  • 4Maloy KJ, Salaun L, Cahill R, et al. CD4^+ CD25^+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms[J]. J Exp Med, 2003,197(1):111-119.
  • 5von Boehmer H. Mechanisms of suppression by suppressor T cells[J]. Nat Immunol, 2005,6(4):338-344.
  • 6Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4^+ CD25^+ T cells mediated suppression by dendritic cells[J]. Science, 2003,299(5609):1033-1036.
  • 7Paust S, Lu L, McCarty N, et al. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease[J]. Proc Natl Acad Sci USA, 2004,101(28):10398-10403.
  • 8Mellor AL, Munn DH. IDO expression by dendritic cells:tolerance and tryptophan eatabolism[J]. Nat Rev Immunol,2004,4 (10) : 762-774.
  • 9Shimizu J, Yamazaki S, Takahashi T, et al. Stimulation of CD25( + )CD4( + ) regulatory T cells through GITR breaks immunological self-tolerance[J]. Nat Immunol, 2002,3 (2) :135-142.
  • 10McHugh RS, Whitters MJ, Piccirillo CA, et al. CD4^+ CD25^+ immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticod-induced TNF receptor[J]. Immunity, 2002,16 (2):311-323.

共引文献17

现代免疫学
2008年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部