摘要
目的从分子水平揭示桃红四物汤治疗损伤血淤证的机制。方法将88只SD大鼠随机均分为11组,即正常对照组、模型组和治疗2、8、24、48、168 h组。制备大鼠损伤血淤证模型,造模后按要求灌胃给药。收集血液,检测血清中肿瘤坏死因子-α(TNF-α)、白介素1β(IL-1β)、白介素8(IL-8)的含量。结果与结论损伤血淤证模型大鼠血清中,TNF-α、IL-1β、IL-8的含量呈现不同时相性变化;桃红四物汤对损伤血淤证模型大鼠血清中TNF-α、IL-1β、IL-8的含量均具有下调作用,但作用时相不同。
OBJECTIVE To explore the essence of traumatic injury with blood stasis syndrome from the molecular level,and to reveal the molecular mechanism of effect of Taohong Siwu decoction on traumatic injury with blood stasis syndrome.METHODS 88 SD rats were randomly divided into 11 groups,which were normal group,model or therapy groups at 2,8,24,48,168 h.Animal model of traumatic injury with blood stasis syndrome by quantitative beating was made.Then the rats were administered by stomach-lawaging.Blood was collecte...
出处
《华西药学杂志》
CAS
CSCD
北大核心
2008年第3期687-688,共2页
West China Journal of Pharmaceutical Sciences
基金
四川省科技厅基金资助项目(05JY029082)
关键词
损伤血淤证
肿瘤坏死因子-Α
白介素1Β
白介素8
桃红四物汤
Traumatic injury with blood stasis syndrome
Tumor necrosis factor–α
Interleukin-1β
Interleukin-8
Taohong Siwu decoction
