血管内皮生长因子受体在骨髓增生异常综合征中的作用研究

Study on the role of the vacular endothelial growth factor receptor in myelodysplasyic syndromes

目的:探讨血管内皮生长因子受体(VEGFR)在骨髓增生异常综合征(MDS)发病机制中的作用。方法:用流式细胞仪测定MDS患者及正常人骨髓单个核细胞VEGFR(VEGFR1和VEGFR2)表达率。结果:VEGFR1阳性表达率结果显示:MDS高危组>MDS低危组>正常组(P<0.01);MDS组和正常组的VEGFR2表达结果无差异(P>0.05)。结论:MDS患者VEGFR1阳性表达增高,VEGFR1阳性表达增高与MDS病程进展有关,提示在MDS转化为白血病过程中VEGFR1起重要作用。

Objective:To investigate the pathogenetic role of the VEGFR in MDS.Methods:The expression of VEGFR was determined by flow cytometry (FCM).Results:All bone marrow mononuclear cells had higher expression of VEGFR1 in MDS than that in the control group (P<0.01).But as to the expression of VEGFR2,there was no difference between these two groups(P>0.05).Conclusion:These data suggest that VEGFR1 is increased in MDS and may play a role in the leukemogenic process.