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凝血栓蛋白-1及P53对非小细胞肺癌组织血管新生的影响及其意义

Angiogenesis and Expression of Thrombospondin-1 and P53 in Non-small Cell Lung Cancer
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摘要 目的:探讨凝血栓蛋白-1、P53及血管内皮生长因子在非小细胞肺癌(NSCLC)中的表达及其与血管新生的关系。方法:用免疫组化SP法检测64例非小细胞肺癌及20例癌旁组织中TSP-1、P53、VEGF的表达及微血管密度值。结果:NSCLC组织中TSP-1的阳性表达率为39.06%,显著低于癌旁组织(P<0.05)。其表达与肺癌的临床分期、淋巴结转移及远处转移有关(P<0.05)。P53在NSCLC组织中的阳性表达率为32.81%,其表达与临床分期及有无远处转移显著相关(P<0.05)。NSCLC组织中的MVD显著高于癌旁组织,与肿瘤的临床分期和远处转移有关(P<0.05)。MVD与TSP-1呈负相关(P<0.05,r=-0.39),与VEGF呈正相关(P<0.05,r=0.44)。TSP-1与VEGF表达呈负相关(P<0.05,r=-0.53),但与P53无相关性。结论:TSP-1与肿瘤的血管新生及侵袭生长关系密切,可能参与了非小细胞肺癌的发生、发展及转移过程,可以作为判断肿瘤侵袭性的参考指标。 Objective:To investigate the expression of thrombospondin-1(TSP-1), P53 and VEGF in human non-small cell lung cancer (NSCLC), and to explore their relationship with microvascular density (MVD). Methods: We examined the expression of TSP-1 protein in 64 patients with NSCLC using immunohistochemistry and studied the relationship with microvascular density, P53 and VEGF expression and clinic pathological factors.Results:The positive expression rate of TSP-1 in NSCLC is lower than that in normal lung tissue. It...
作者 朱吉海 达嘎 李勇 武建英
机构地区 青海大学医学院 青海大学附属医院
出处 《青海医药杂志》 2008年第3期4-8,共5页 Qinghai Medical Journal
关键词 凝血栓蛋白-1 微血管密度 免疫组织化学 非小细胞肺癌 Thrombospondin-1 Microvascular density Immunohistochemistry Non-small cell lung cancer
分类号 R734.2 [医药卫生—肿瘤]
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参考文献15

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青海医药杂志
2008年 第3期

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