摘要
目的研究卡托普利对甲亢大鼠心肌的保护作用。方法大鼠ig左甲状腺素钠片14 d,测定血清中FT3、FT4、TSH,制作大鼠甲亢模型;分组给药治疗14 d后,再次测定大鼠血清中FT3、FT4、TSH,并检测大鼠心肌MDA的含量、SOD和GSH-PX酶的活性。结果丙基硫氧嘧啶、卡托普利、丙基硫氧嘧啶联合卡托普利3组均可降低大鼠血清中FT3、FT4,升高TSH;丙基硫氧嘧啶及卡托普利单独给药具有降低MDA含量、升高SOD活性的趋势;丙基硫氧嘧啶+卡托普利给药可显著降低心肌MDA含量,升高SOD、GSH-PX酶活性(P<0.01)。结论给予卡托普利后,较单纯丙基硫氧嘧啶抗甲亢治疗具有明显的心肌保护作用。
OBJECTIVE To study the protective effects of Captopril on hyperthyroid rats.METHODS After establishing hyperthyroid rats model using levothyroxine sodium tablets,the rats were randomized to five groups: the normal group,the control group,the Propylthiouracil group,the Captopril group and the Propylthiouracil plus Captopril group respectively.After 14 days,the content of FT3,FT4 and TSH was examined to confirm whether the hyperthyroid rats model was made successfully.After 28 days,MDA content and SOD activit...
出处
《华西药学杂志》
CAS
CSCD
北大核心
2008年第4期422-423,共2页
West China Journal of Pharmaceutical Sciences
关键词
甲亢
心肌损伤
卡托普利
丙基硫氧嘧啶
Hyperthyroid
Myocardial injury
Captopril
Propylthiouracil
