摘要
目的制备用于基因治疗的靶向药物中间体胆固醇胺。方法以甲磺酸酯为起始原料,经醚化、磺酰化、取代、还原反应得到目标化合物。结果所有化合物的结构均经1HNMR,IR,MS予以确证。结论该路线设计合理,方法可行。
OBJECTIVE To synthesize an intermediate-cholesterylated amine for gene delivery.METHODS We started from mesylate 2,after etherification,mesylation,azidation and reduction to achieve target compound.RESULTS The structures of compounds were confirmed by 1HNMR,IR and MS.CONCLUSION The synthetic route is rational and feasible.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2008年第4期379-380,共2页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金(批准号:30672537)
高等学校博士学科点专项科研基金资助(批准号:20050610085)
关键词
靶向药物
胆固醇胺
合成
Drug targeting
Cholesterylated amine
Synthesis
