三味檀香水提液对大鼠离体主动脉环的作用

Effects of the aquatic extraction of Sanwei Tanxiang on isolated rat aortic strips

目的探讨三味檀香水提液(ESWTX)对离体大鼠主动脉环的舒张作用。方法采用离体大鼠主动脉环张力记录法,观察ESWTX对去甲肾上腺素(NE)、KCl引起的血管平滑肌收缩的影响。结果ESWTX能使NE、KCl收缩血管平滑肌的最大反应下降,作用机制与维拉帕米相似;对NE、KCl收缩达峰值的离体大鼠主动脉环有舒张作用;对NE引起的依赖于细胞内钙收缩有明显的抑制作用,而对外钙收缩的抑制作用比较弱。结论ESWTX的作用类似于维拉帕米,具有舒张血管平滑肌的作用,其机制可能与拮抗钙离子有关。

OBJECTIVE To evaluate the effect of the aquatic extraction of Sanwei Tanxiang on relaxant behavior of isdated rat aortas.METHODS Vitro Experiment method of smooth muscle was used to observe the effects of the aquatic extraction of Sanwei Tanxiang on vascular smooth muscle s contraction after adding NE,KCl.RESULTS The aquatic extraction of Sanwei Tanxiang would enable dropping down of the effect of vascular smooth muscle′s contraction induced by KCl,NE,and its mechanism was similar to Ver.Sanwei Tanxiang had...