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抗癫癎药物与大鼠海马CA1区胶质细胞TUNEL阳性表达关系的研究 被引量：2

The study of relationship between anti-epileptic drug with Hippocampus neuron TUNEL positive express
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摘要 目的:探讨抗癫癎药物对大鼠海马胶质细胞凋亡的影响。方法:35只60天龄SD大鼠随机分为生理盐水组(NS)、戊四氮(PTZ)组、卡马西平组(CBZ)、丙戊酸钠组(VPA)、苯妥英钠组(PHT)、托吡酯组(TPM)、拉莫三嗪组(LTG)7组,起始体重(200±20)g,戊四氮点燃其中6组制作癫癎模型,再给与抗癫癎药物治疗3周,应用TUNEL法观察大鼠海马胶质细胞的阳性表达率。结果:CA1区胶质细胞TUNEL阳性表达:NS组阳性率4.195%,PTZ组阳性率6.536%,CBZ组阳性率4.321%,VPA组阳性率5.587%,4组之间TUNEL阳性表达率差异无显著性(χ2=1.158,P>0.05);PHT组阳性率24.460%,TPM组阳性率21.605%,LTG组阳性率18.902%,三组之间TUNEL阳性表达率差异无显著性(χ2=1.378,P>0.05)。NS组、PTZ组、CBZ组、VPA组与PHT组、TPM组、LTG组之间TUNEL阳性表达率差异有显著性(χ2=70.227,P<0.005)。结论:大鼠癫癎模型经PTH、TPM、LTG治疗后,海马CA1区存在TUNEL阳性胶质细胞。 Objective:To explore the relationship of antiepileptic drugs with apoptosis of hippocamp astrocytes.Methods:35 adolecence male Sprague-Dawley rats,weighting(200±20)g,were divided into seven groups randomly :normal control group(NS group),status epileptics group(Pentylenetetrazole,PTZ group),carbamazepine(CBZ)group,valproate sodium(VPA)group,phenytoin(PHT)group,topiramate(TPM)group,lamotrigine(LTG)group.Besides NS group,they were kindling by PTZ,then they were treated by antiepileptic drugs(AEDs).Three weeks...
作者 王晓鹏 王维平 刘瑞春 耿连霞 吴丽玲 刘惠苗 杨兰 卜志平
机构地区 河北医科大学第二医院神经内科
出处 《脑与神经疾病杂志》 2008年第3期210-212,187,共4页 Journal of Brain and Nervous Diseases
基金 河北省自然科学技术C2007000851
关键词 抗癫癎药物 海马神经胶质细胞 凋亡 戊四氮 antiepileptic drugs Pentylenetetrazole hippocampus astrocytes apoptosis
分类号 R965 [医药卫生—药理学]
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参考文献12

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共引文献13

同被引文献21

  • 1郭志松,娄季宇,李平,王金兰,杨霄鹏,蒋超.拉莫三嗪对大鼠脑出血后血肿周围兴奋性氨基酸受体亚基NR1和GluR2表达变化的影响[J].中国实用神经疾病杂志,2007,10(3):89-91. 被引量：3
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引证文献2

二级引证文献5

脑与神经疾病杂志
2008年 第3期

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