三唑酮与阿米替林治疗复发性抑郁症的临床对照研究

A Control Study of Trazodone and Amitriptylin in the Treatment of Recurrent Depression

目的探讨三唑酮治疗复发性抑郁症的疗效与安全性。方法将入组病人随机分为两组各60例,分别应用三唑酮和阿米替林治疗,疗程28天,用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)评定疗效和副反应。结果治疗28天后,两组对复发性抑郁症均有良好疗效。三唑酮与阿米替林疗效近似,两组相比,差异无显著性(P>0.05);但三唑酮副反应小,程度较轻,两组相比,在统计学上有显著性差异(P<0.05或P<0.01)。结论三唑酮治疗复发性抑郁症疗效确切而安全。

Objective To explore the efficacy and safety of trazodone in the treatment of Recurrent depression. Methods 120 Recurrent depression patients meeting entrance condition were randomly divided into two groups were treated with trazodone and amitriptylin respectively for 4 weeks, The therapeutic response and side effects were evaluated with the HAMD and TESS. Results Trazodone and amitriptylin showed good effect in the treatment of recurrent depression, Trazodone had similar efficacy to amitriptylin and the c...