摘要
目的探讨嗜肺军团菌与非嗜肺军团菌感染所致社区获得性肺炎的临床特点,提高对军团菌肺炎的认识。方法采用双重聚合酶链反应(DPCR)法对根据临床表现及血清抗体结果,临床诊断为军团菌肺炎患者的痰标本进行军团菌DNA检测。选择痰DPCR和血清抗体结果呈一致阳性的患者并根据检测结果将其分为嗜肺军团菌肺炎组(42例)和非嗜肺军团菌肺炎组(18例)。将2组患者的临床资料进行对比分析。结果痰标本DPCR结果与血清特异性抗体结果呈一致阳性,嗜肺军团菌肺炎与非嗜肺军团菌肺炎诊断明确。嗜肺军团菌肺炎多发于既往体健的青壮年,主要发病于夏秋季;非嗜肺军团菌倾向于四季散发,多发于有基础疾病的老年人。与非嗜肺军团菌肺炎相比,嗜肺军团菌肺炎患者的肺脏受累面积较大,胸腔积液及ARDS发病率高,同时全身感染中毒症状和肺外表现更为明显(P<0.05)。结论嗜肺与非嗜肺军团菌感染所致社区获得性肺炎临床特点有所不同,早期予大环内酯类/喹诺酮类抗生素治疗是改善预后的关键手段。
Objective To investigate the clinical features of community acquired pneumonia(CAP) due to Legionella pneumophila(Lp) and non-pneumophila Legionella species(non-Lp).Methods Sputum samples from patients with clinically diagnosed legionella pneumonia according to manifestations and serum antibody results were detected for legionella DNA with a duplex polymerase chain reaction(DPCR)method.Patients with the coincident positive results of sputum DPCR and serum antibody were divided into Lp pneumonia group(42 cas...
出处
《首都医科大学学报》
CAS
2008年第3期348-353,共6页
Journal of Capital Medical University
关键词
社区获得性肺炎
嗜肺军团菌
非嗜肺军团菌
双重聚合酶链反应
community acquired pneumonia
Legionella pneumophila
non-pneumophila Legionella species
duplex polymerase chain reaction
