血小板活化与冠状动脉粥样硬化性心脏病和血瘀证的关系

The Relationship between Platelet Activation and Coronary Heart Disease and Blood-stasis Syndrome

血小板膜糖蛋白在血小板黏附、聚集和释放反应中起关键作用,是血小板活化的特异性分子标志物。研究证实血小板膜糖蛋白,特别是CD62P、CD63和PAC-1的活性检测可较为灵敏且特异地反映冠状动脉粥样硬化性心脏病(冠心病)的发生发展过程,且随着病情程度的加重上述糖蛋白的表达也相应增强。血瘀证是临床最常见证候之一,研究证实多种疾病的血瘀证患者存在血小板活化现象,而不同病种之间的血小板活化表达量则无明显差异。活化血小板膜糖蛋白测定不仅可以对冠心病,特别是急性心肌梗死的早期诊断、病程进展判断等起辅助作用,还可作为血瘀证的微观辨证指标之一。

The platelet membrane glycoprotein plays a key role in the adhesion,aggregation and release of platelets,and is the specific marker for platelet activation.Many studies have shown that the activity of the platelet membrane glycoprotein,especially CD62P,CD63 and PAC-1,can reflect the pathogenesis and development of coronary heart disease sensitively and specifically,and its expression can be influenced by the pathological conditions.Blood-stasis syndrome is one of the most common clinical syndromes.Patients ...