摘要
目的:研究慢性心力衰竭(CHF)患者血红蛋白(Hb)、血清肿瘤坏死因子(TNF-α)和(AngⅡ)水平的变化及其干预治疗。方法:对入选的319例CHF患者分为A组和B组,并按Hb水平分为贫血组和非贫血组,于治疗前后测定了Hb、血清TNF-α和AngⅡ水平,超声心动图测量左室射血分数(LVEF),评价心功能。结果:随着心功能恶化,Hb水平逐渐降低,而血清TNF-α和AngⅡ水平逐渐升高;CHF贫血组患者血清TNF-α和AngⅡ水平明显高于非贫血组患者(P<0.01);CHF患者Hb水平与TNF-α和AngⅡ水平呈负相关(P<0.01)。采用不同方案治疗后的结果显示,联合用药治疗CHF患者优于单一药物;CHF贫血患者在贫血纠正后,血清TNF-α和AngⅡ水平恢复到非贫血组患者水平。结论:TNF-α和AngⅡ在CHF贫血发生发展的病理生理过程中起着重要作用;积极纠正贫血,规范的治疗可显著降低血清TNF-α和AngⅡ水平,从而改善CHF患者心脏功能和预后。
Objective:To study the changes of hemoglobin (Hb) concentration, tumor necrosis factor-α (TNF-α), AngiotensinⅡ (AngⅡ), and the effect of intervention on Hb concentration and parameters in patients with congestive heart failure (CHF). Methods: 319 patients with CHF were divided into two group: the A group and B group. Blood samples were drawn from mediam cubital veins of the patient at the beginning of the study and follow-up after the 6-month.Hb concentration, serum level of TNF-α and AngⅡ were measured. Le...
出处
《青海医药杂志》
2008年第2期1-5,共5页
Qinghai Medical Journal
基金
青海省科技厅自然科学基金项目课题(项目编号2006-N-149)