银杏黄酮甙治疗肺间质纤维化疗效与免疫细胞因子相关性研究

Correlation Between Curative Effect of Gingko Flavonoid Glycosides on IPF and Immune Cytokines

目的观察银杏黄酮甙(银杏叶提取物)治疗肺间质纤维化的临床疗效及与免疫细胞因子的相关性。方法将所收治的45例肺间质纤维化患者随机分为2组,治疗组口服银杏叶胶囊,对照组口服强的松,治疗3个月,观察各组治疗前后在症状、肺功能等方面的改善情况及白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子α(TNF-α)情况的变化。结果总有效率治疗组为80.00%,对照组为66.67%;2组治疗前后肺总量(TLC)、肺活量(VC)、肺弥散功能(DLco)、IL-6、IL-8、TNF-α自身对照,有显著差异(P<0.05)。结论银杏黄酮甙治疗肺间质纤维化有一定疗效并与免疫细胞因子有一定相关性。

Objective To observe the curative effect of gingko flavonoid glycosides (ginkgo leaf extract, EGB761) on interstitial pulmonary fibrosis (IPF) and the correlation between the curative effect and immune cytokines. Method The patients with IPF (n=45) were randomly divided into two groups. Group 1 was given Yinxingye Capsules orally and group 2 was given prednisone for 3 months respectively. The relief of symptoms and improvement of lung function, the changes of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) were observed before and after the treatment. Result The total effective rate was 80.00% in group 1 and that in group 2, 66.67 %. There were significant differences (P<0.05) in the total lung capacity (TLC), vital capacity (VC), diffusing capacity (Dlco), IL-6, IL-8 and TNF-α in two groups before and after the treatment. Conclusion Gingko flavonoid glycosides has a curative effect on IPF and has the correlation with immune cytokines.