复方岗梅冲剂对小鼠咳嗽反射的抑制作用的研究

Antitussive effect of Gangmei Compound Granules in mice

目的观察复方岗梅冲剂的镇咳作用。方法小鼠氨水引咳法:将小鼠分成个5组:复方岗梅冲剂高剂量组和低剂量组、可待因组、强的松组和蒸馏水对照组:比较5组小鼠对用氨水雾化吸入后小鼠出现咳嗽的潜伏期和对氨水雾化吸入引起小鼠咳嗽反射的抑制作用。结果复方岗梅冲剂低剂量组和高剂量组明显抑制氨水引起的小鼠咳嗽次数,但对咳嗽潜伏期无明显影响。结论复方岗梅冲剂能明显减少氨水雾化引起小鼠咳嗽作用。

OBJECTIVE To study the antitussive effect of gangmei compound granules.METHODS The cough induced by ammonia water in mice:The mice were divided into five groups.Such as gangmei compound granules high dosage groups and low dosage groups,codeine groups,prednisolone groups,distilled water groups.The cough incubation period and the cough reflex induced by inhalation of ammonia water aerosol was evaluated in mice.RESULTS The gangmei compound granules high dosage groups,low dosage groups,codeine groups,prednisolone groups had no significant than the distilled water groups on the cough incubation period induced by inhalation of ammonia water aerosol in mice(P>0.1).The gangmei compound granules high dosage groups and low dosage groups had very significant than the distilled water groups on antitussive effect induced by inhalation of ammonia water aerosol in mice(P<0.01);codeine groups had significant effects(P<0.05).prednisolone groups had a little effects(0.05<P<0.1).CONCLUSION The gangmei compound granules had significant antitussive effect induced by inhalation of ammonia water aerosol in mice.it agrees with that the gangmei compound granules had antitussive effect induced by pharyngitis and laryngitis in man.