磷霉素钠不良反应分析

An analysis of aderse reactions induced by fosfomycin sodium

目的对磷霉素钠不良反应发生的情况进行分析,为临床合理用药提供参考。方法对国内近10年使用磷霉素钠出现的115例不良反应报道进行分类统计与分析。结果 115例涉及的不良反应有皮肤、黏膜过敏反应30例(26.09%),严重过敏反应27例(23.48%),过敏性休克25例(21.74%),神经系统损害9例(7.83%),低钙血症6例(5.22%),肺水肿4例(3.48%),死亡3例(2.61%),药物热3例(2.61%),心脏损害2例(1.74%)等。结论临床医师、药师与护士应重视磷霉素钠的不良反应。

OBJECTIVE To analyze the ADRs caused by Fosfomycin Sodium and to provide some guidance for clinical medicine and rational drug use.METHOD By arranging,classifying and analyzing the reports of ADRs induced by Fosfomycin Sodium used through domestic literature in recent ten years.RESULT 115 cases with ADRs were analyzed,such as skin and mucosa allergic response(30),Severity allergic response(27),allergic shock(25),nervous system damage(9),hypocalcemia(6),pneumonedema(4),death(3),drug fever(3),heart damage(2),et al.CONCLUSION Clinical physicians,pharmacists and nurses should pay more attention to the ADRs Of Fosfomycin Sodium.