摘要
目的建立鼻宝片中扑尔敏的含量测定方法。方法分别采用甲基橙、锌试剂与扑尔敏络合,用二氯甲烷萃取,分光光度法测定鼻宝片中扑尔敏的含量。结果锌试剂法:扑尔敏在2.3~20.2μg·L^(-1)浓度范围内线性关系良好,平均回收率98.5%,RSD=1.60%。甲基橙法:扑尔敏在2.0~11.6μg·L^(-1)浓度范围内线性关系良好,平均回收99.2%,RSD=1.2%。结论两种方法均能排除干扰,结果稳定。操作简单易行,可作该片中扑尔敏含量测定方法。
OBJECTIVE To develop a method to determinate the content of Chlorpheniramine Mateate in Bibao Tablet.METHODS The content of Chlopheniramine Maleate in Bibao Tablet was determined by Zincon or methyl-orange complexometric extractionspectrophotometry.RESULTS The calibration curve was linear.When complexed with Zincon the linear concentration rang from 2.3~20.2μg·mL^(-1) with average recovery rate 98.5%and RSD = 1.60%.When complexed with methyl-orange,the lineae comcentraction range is 2.0 ~11.6μg·L^(-1),with average recouery rate 99.0%and RSD = 1.2.CONCLUSION Both methods are accurate,simple and reliable,and have no interference from other components in the tablet.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2005年第z2期744-745,共2页
Chinese Journal of Modern Applied Pharmacy
关键词
鼻宝片
扑尔敏
含量测定
甲基橙
锌试剂
Bibao Tallet
Chlorpheniramine Maleate
Determination of content
Zincon
Methy-orange