拉米夫定对慢性乙肝患者的血清瘦素水平的影响

The effects of lamivudine on serum leptin levels in patients with chronic hepatitis B

目的观察拉米夫定治疗后慢性乙型肝炎患者血清瘦素水平的变化,以探讨拉米夫定抗肝纤维化的机制。方法慢性乙型肝炎患者42例用拉米夫定抗病毒治疗,拉米夫定100mg每日1次,连续用1年。用ELISA法检测患者治疗前后的血清瘦素水平。结果拉米夫定治疗1年后,慢性乙肝患者的血清瘦素水平由(4.67±6.65)ng/mL降为(2.46±3.86)ng/mL(t=2.574,P=0.014);患者的HBVDNA水平下降(5.42±3.08)lgcopis/mL(t=11.406,P<0.001)。结论经拉米夫定治疗后,慢性乙型肝炎患者血清瘦素水平显著下降;拉米夫定可能通过降低慢性乙型肝炎患者的血清瘦素水平而影响肝纤维化的进展。

OBJECTIVE To observe the changes of surem leptin levels in patients with chronic hepatitis B after lamivudine therapy,and to discuss anti-fibronic mechanism of lamivudine.METHODS Forty-two patients with chronic hepatitis B(33 men,9 womem.mean age:26.33 ±7.22 years) were included in this study.Lamivudine was administrated 100 mg once per day for 1 year.Serum leptin levels were determined by means of enzyme-linked immunosorbent assay(ELISA).RESULTS At the end of 1 year lamivudine treatment,serum leptin levels in patients with chronic hepatitis B significantly decreased from 4.67 ±6.65ng/mL to 2.46 ± 3.86ng/mL(t = 2.574,P =0.014),the level of HBVDNA also significantly decreased 5.42 ±3.08 lgcopis/mL(t = 11.406,P<0.001).CONCLUSION In patients with chronic hepatitis B,serum leptin levels significantly decreased after lamivudine treatment;lamivudine affected the development of liver fibrosis might by way of decreasing leptin expression.