多巴胺受体激动剂的神经保护作用

Neuroprotective effect of dopamine receptor agonists

左旋多巴和多巴胺受体激动剂是目前主 要应用于治疗帕金森病的药物。但近年来在体和离 体研究显示左旋多巴可能对多巴胺神经元有神经毒 性,而多巴胺受体激动剂对黑质纹状体系统的神经 元具有保护作用。这种神经保护作用可能是通过抗 氧化、神经营养、抗凋亡和稳定线粒体膜的机制实现 的。本文回顾了近年来多巴胺受体激动剂神经保护 作用的机制研究,认为这类药物除了具有症状改善 作用外,还可能具有延缓帕金森病病程进展的作用。

Levodopa and dopamine receptor agonists are the main therapeutic drugs currently used for Parkinson's disease (PD). However recently in vitro and in vivo studies have revealed that levodopa may be neurotoxic to dopamine neuron, while dopamine receptor agonists may have neuroprotective effect against neuronal injury in the nigro-striatal system. This neuroprotective effect of dopamine receptor agonists may resulted from the mechanism through their properties concerning about the antioxidation, neurotrophic stimulation, antiapoptosis and mitochondrial membrane potential stabilization. This paper retrospectively present the evidences and mechanisms of neuroprotection provided by several dopamine receptor agonists, such as apomorphine, pramipexole and ropinirole, and suggests that these drugs may be able to slow down the progression of the disease in addition to their symptomatic relief of PD.