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他汀类药物对多发性硬化的辅助治疗作用 被引量：4

Adjunctive therapeutic effects of statins on multiple sclerosis
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摘要 他汀类药物可通过减少T细胞激活、抑制 T细胞迁移、使Th1类细胞反应向Th2类细胞反应 转化以及下调中枢神经系统炎症介质来抑制多发性 硬化的自身免疫反应。这些反应并非通过调节胆固 醇代谢,而是通过其抗炎症作用而达到的。临床上 采用他汀类药物治疗多发性硬化已经取得初步成 功。他汀类药物是多发性硬化治疗中有希望的辅助 药物。 Statins may inhibit autoimmune reactions of multiple sclerosis (MS) by reducing T cell activation, inhibiting T cell migration, converting Th1 cell reaction to Th2 cell reaction and down-regulating central nervous system inflammatory mediator. These effects are the results of their anti-inflammatory mechanism in stead of their cholesterol regulating mechanism. Preliminary clinical effects of statins on MS have been achieved as a promising adjunctive therapty.
作者 李海峰
机构地区 青岛大学医学院附属医院神经内科
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2005年第2期155-159,共5页 Chinese Journal of New Drugs and Clinical Remedies
关键词 多发性硬化 药物疗法 自身免疫疾病 他汀类 multiple sclerosis drug therapy autoimmune diseases statins
分类号 R744.51 [医药卫生—神经病学与精神病学] R972.6 [医药卫生—药品]
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参考文献26

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  • 4[4]MERONI PL,LUZZANA C,VENTURA D.Anti-inflammatory and immunomodulating properties of statins.An additional tool for the therapeutic approach of systemic autoimmune diseases? [J].Clin Rev Allergy Immunol,2002,23(3):263-277.
  • 5[5]LEUNG BP,SATTAR N,CRILLY A,et al.A novel anti-inflammatory role for simvastatin in inflammatory arthritis [J].J Immunol,2003,170(3):1524-1530.
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  • 7[7]STANISLAUS R,PAHAN K,SINGH AK,et al.Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin [J].Neurosci Lett,1999,269(2):71-74.
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中国新药与临床杂志
2005年 第2期

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