A型肉毒毒素治疗偏头痛的临床研究

Botulinum toxin type A as an effective prophylactic treatment in migraine: an open-label study

目的:观察A型肉毒毒素治疗预防偏头痛 发作的临床疗效和不良反应。方法:选取30例偏头 痛病人,应用A型肉毒毒素进行颅周肌内注射治 疗,问卷调查记录每例偏头痛病人治疗前3mo,治 疗后mo1,2,3偏头痛发作情况,比较偏头痛发作频 率、发作持续时间、发作严重程度及使用止痛药物情 况,观察不良反应。结果:A型肉毒毒素治疗后 mo1,偏头痛发作频率、发作持续时间、发作严重程 度均较治疗前明显下降(P<0.01),止痛药物的使 用较治疗前减少(P<0.01),疗效可至少维持3mo, 且不良反应轻微、短暂。结论:A型肉毒毒素颅周肌 内注射治疗预防偏头痛发作临床疗效显著,不良反 应轻微、短暂,值得临床研究。

AIM: To evaluate the efficacy and adverse reactions of botulinum toxin type A in migraine prophylaxis. METHODS: We performed a 3-month open study that enrolled 30 adult migraineurs, and botulinum toxin type A was injected into multiple sites of pericranial muscles. During a 3-month baseline period and other 3 mo following injection, subjects kept daily diaries recording migraine frequency, duration and severity together with acute migraine medication usage, and the occurrence of treatment-related adverse reactions. RESULTS: After comparing with those of pretreatment, subjects received pericranial intramuscular administration of botulinum toxin type A, showed significant reduction for migraine attacks per month, mean duration and severity of migraines. Furthermore, a reduced acute migraine medication usage for at least three months(P<0.01), and no severe treatment-related adverse reactions were observed. CONCLUSION: Pericranial intramuscular injection of botulinum toxin type A is a safe and effective treatment significantly reducing the frequency, severity, duration, and acute medication usage of migraine.