期刊文献+

他汀类药物在肾脏疾病中抗炎作用的研究现状

INHIBITORY EFFECTS OF STATINS ON INFLAMMATION IN RENAL DISEASES
下载PDF
导出
摘要 他汀类药物即3-羟基3-甲基戊二酸单酰辅酶A(HM G-CoA)还原酶抑制剂。近年的研究发现他汀类药物不但具有降血脂作用,同时还具有一定的肾保护作用。这种作用并非完全由他汀类药物的降脂作用引起,这类药物还具有非降脂相关的肾保护作用,抑制炎症过程是直接肾脏保护作用的重要机制之一。本文就他汀类药物在肾脏疾病中的抗炎作用的研究新进展作一综述。 Statins are 3-hydroxy-3-methylgluraryl co-enzyme A reductase inhibitors.Recently many clinical trials have shown that statins can not only reduce the serum cholesterol level,but protect renal function.And the renal protective effect of statins is independent of cholesterolol-lowering.One of the mechanisms is the statins can inhibit inflammatory process.This thesis emphasizes on the advances that statins have limit inflammation in renal diseases.
出处 《内蒙古医学院学报》 2005年第5期96-99,共4页 Acta Academiae Medicinae Neimongol
关键词 他汀类药物 肾脏 抗炎 statins renal inhibit inflammation
  • 相关文献

参考文献16

  • 1[1]Attman PO,Alaupovic P,Samuelsson O.Lipoprotein abnormalities as a risk factor for progressive nondiabetic renal diaease [J].Kidney Int,1999;71:S14-17
  • 2[2]Myles Joyce.Pravastatin 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor attenuates renal injury in an experimental model of ischemia-reperfusion [J].J Surg Res,2001;101 (1):79-84
  • 3[3]Jandeleit Dahm K,Cao Z,Cox AJ,et al.Role of hyperlipidemia in progressive renal disease focus on diabetic nephropathy[J].Kidney Int Suppl,1999;71:S31-36
  • 4[4]Elisaf M,Mikhalids DP.Statins and renal function[J].Angiology,2002;53 (5):493-502
  • 5[5]Nakamura T,Ushiyama C,Hirokawa K,et al.Effect of cerivastatin on proteinuria and urinary podocytes in patients with chronic glomerulonephritis[J].Nephrol Dial Transplant,2002;17(5):798-802
  • 6[6]Yukawa S,Mune M,Yamada Y,et al.Ongoing clinical trials of lipid reduction therapy in patients with renal disease[J].Kidney Int Suppl,1999;71:S141-143
  • 7[7]Sarkis B,Baghdasarian,Hani Jneid,et al.Association of dyslipidemia and effects of statins on nonmacrovascular diseases[J].Clin Therap,2004;26(3):337-351
  • 8[8]Katznelson S,Wilkinson AH,Kobashigawa JA,et al.The effect of pravastatin on acute rejection after kidney transplantation-a pilot study [ J].Transplantation,1996;61 (10):1469-1474
  • 9[9]Pisana A,Uccello F,Cesaro A,et al.Effects of atorvastatin on ischemic acute renal failure in aging rats[J].G Ital Nefrol,2002;19(5):534-539
  • 10[10]Yamashira T,Kawashima S,Miwa Y,et al.A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke prone spontaneously hypertensive rats [J].J Hypertens,2002;20 (12):2465-2473

二级参考文献10

  • 1Mital S,Zhang X,Zhao G,et al.Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs[].American Journal of Physiology Heart and Circulatory Physiology.2000
  • 2Laufsi U,Marrai D,Node K,et al.3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase- induced down-regulation of p27 kipl[].Journal of Biological Chemistry.1999
  • 3Muller C,Kiehl MG,Van de loo J,et al.Lovastatin induces p21WAF1/Cip1 in human vascular smooth muscle cells: influence on protein phosphorylation, cell cycle, induction of apoptosis, and growth inhibition[].International Journal of Molecular Medicine.1999
  • 4Hausding M,Witteck A,Rodriguez-Pascual F,et al.Inhibition of small G proteins of the rho family by statins or clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II[].British Journal of Pharmacology.2000
  • 5Kawata S,Yamasaki E,Nagase T,et al.Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma, A randomized controlled trial[].British Journal of Cancer.2001
  • 6Porreca E,Di-Febbo L,Amore C,et al.Effect of lipid-lowering treatment on factor VII profile in hyperlipidemic patients[].Thrombosis and Haemostasis.2000
  • 7Strehlow K,Wassmann S,Bohm M,et al.Angiotensin AT1 receptor over-expression in hypercholesterolaemia[].Annals of Medicine.2000
  • 8Park JK,Muller DN,Mervaala EM,et al.Cerivastatin prevents angiotensin II-induced renal injury independent of blood pressure and cholesterol-lowering effects[].Kidney International.2000
  • 9Ganne F,Vasse M,Beaudeux JL,et al.Cerivastatin, an inhibitor of HMG-COA reductase, inhibits urokinase/urokinase-receptor expression and MMP-9 secretion by peripheral blood monocytes--a possible protective mechanism against atherothrombosis[].Thrombosis and Haemostasis.2000
  • 10Dimitroulakos J,Ye LY,Benzaquen M,et al.Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin - induced apoptosis: therapeutic implications[].Clinical Cancer Research.2001

共引文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部