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P14^(ARF)与肿瘤

P14^(ARF) And Tumor
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摘要 INK4 a/ARF基因编码有两个独立的蛋白,即p16INK4 a和p14ARF。其中p14ARF对MDM2-p53通路具有关键性调控作用。在人类的很多肿瘤中发现p14ARF基因位点存在改变。随着国内外研究的增多,p14ARF成为肿瘤研究的热点,本文将对p14ARF的结构、抑癌机理及其功能失活机制作一综述。 INK4a/ARF locus encodes two products,p16INK4aand p14ARF,the later plays an important rolein controlling the MDM2-p53 tumor suppressor pathway.Inactivation of p14ARFgene happened frequently in hu-man cancers.With accumulation of study issues p14ARFhave become a hotspot.Here is a reviewof its structure,mechanism of tumor suppression and inactivation.
作者 张华 李秀霞
机构地区 内蒙古医学院病理教研室
出处 《内蒙古医学院学报》 2005年第6期61-63,67,共4页 Acta Academiae Medicinae Neimongol
关键词 P14ARF 肿瘤 p14ARF tumor
分类号 R734.2 [医药卫生—肿瘤]
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  • 1Morrissey C, Martinez A, Zatyka M, et al. Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear ceel and papillary renal cell carcinoma. Cancer Res, 2001,61(19) :7277-7281.
  • 2Yoon JH,Dammann R, Heifer GP.Hypermethylation of the CpG island of the RASSF1A gene in overian and renal cell carcinomas. Int J Cancer,2001,94(2) :212-217
  • 3Lee MG, Kim HY, Byun DS, et al. Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma. Cancer Res, 2001,61(18) :6688-6692.
  • 4Agathanggelou A, Honorio S,Macartney DP, et al. Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours. Oncogene, 2001,20(12) :1509-1518.
  • 5Khokhlatchev A, Rabizadeh S, Xavier R, et al. Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol, 2002,12(4) :253-265.
  • 6Ortic-Vega S, Khokhlatchev A, Nedwidek M, et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Norel. Oncogene, 2002,21(9): 1381-1390.
  • 7Vos MD, Ellis CA, Bell A, et al. Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J Biol Chem, 2000,275(46):35669-35672.
  • 8Vos MD, Ellis CA, Elam C,et al. RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor. J Biol Chem, 2003,278 (30): 28045-28051.
  • 9Isa T, Tomita S, N.akachi A, et al. Analysis of microsatellite instability, Kras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma. Hepatogastroenterology, 2002,49(45) :604-608.
  • 10Van Engeland M, Roemen GM, Brink M, et al. K-ras mutations and RASSF1A promoter methylation in colorectal cancer. Oncogene, 2002,21(23): 3792-3795.

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内蒙古医学院学报
2005年 第6期

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