高效液相色谱-大气压化学电离质谱分析双(2-羟乙基)砜

Analysis of Bis(2-hydroxyethyl)sulfone by High Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionisation Mass Spectrometry

利用高效液相色谱-大气压电离质谱(HPLC-APCI-MS)对硫芥子气的氧化产物之一双(2-羟乙基)砜进行了测定,优化了获得最佳准分子离子峰的探头温度和锥体电压,最低检出限为0.4 ng(S/N>3),利用源内CID技术获得了丰富的离子碎片,并对碎片进行了解释,同时对禁止化学武器组织(OPCW)第十五轮水平考试中水样品中的双(2-羟乙基)砜进行了28天的定性、定量分析。

High performance liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry(HPLC-APCI-MS) was used to analyze bis(2-hydroxyethyl)sulfone,the degradation product of sulphur mustard.The conditions of HPLC-APCI-MS were optimized under the probe temperature and cone voltage to facilitate acquisition of optimal molecular ion.The data were collected under collision induced dissociation(CID) conditions to facilitate acquisition of product ion information that could be used for structural identification purposes.The detection limit was at 0.4 ng.The method was successfully applied to qualitative and quantitative analysis of bis(2-hydroxyethyl)sulfone in aqueous samples of the 15th official OPCW(Organisation for the Prohibition of Chemical Weapons) proficiency test within 28 days.