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UGT1A1 TATA突变对G6PD缺乏新生儿高胆红素血症的影响 被引量：3

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摘要 目的:探讨葡萄糖醛酸转移酶UGT1A1 TATA对葡萄糖-6-磷酸脱氢酶(G6PD)缺乏新生儿高胆红素血症(高胆)发病的作用。方法:测定109例新生儿G6PD活性及TATA基因型。用单链构象多态性分析(PCR-SSCP)检测TATA突变。结果:所有新生儿或TATA野生型新生儿中,G6PD缺乏组高胆发生率及其危险性增加。G6PD缺乏并存有TATA突变杂合子组的高胆发生率与G6PD正常且TATA为野生型组相比,差异无统计学意义(P>0·05)。G6PD正常新生儿中,TATA突变杂合子组高胆发生率与TATA野生型组相比,差异亦无统计学意义(P>0·05)。结论:TATA基因型与新生儿高胆的发病无关。G6PD缺乏同时存在TATA突变杂合子的状态与新生儿高胆的发病亦无关。
作者 傅雯萍 刘义
机构地区 天津武警医学院附属医院儿科 广西医科大学第一附院儿科
出处 《广西医学院学报》 北大核心 2008年第2期262-263,共2页
关键词 葡萄糖-6-磷酸脱氢酶缺陷症 新生儿 高胆红素血症 UGT1A1基因
分类号 R722.1 [医药卫生—儿科]
  • 相关文献

参考文献8

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二级参考文献1

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共引文献358

同被引文献28

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引证文献3

二级引证文献18

广西医学院学报
2008年 第2期

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