摘要
目的:研究克糖特(KTT)对糖尿病模型小鼠血糖的影响,并初步探讨其降低小鼠血糖的作用机制。方法:建立肾上腺素致高血糖小鼠模型和链脲霉素(STZ)致糖尿病小鼠模型,并将小鼠随机分成5组(n=10),分别用格列本脲(50mg/kg)、克糖特高、中、低剂量和生理盐水(0·1mL/10g体重)灌胃15d。15d后测定正常小鼠、肾上腺素致高血糖小鼠模型的血糖水平,并在相应时间采血测定STZ致糖尿病小鼠模型空腹血糖(FBG)、药后2h血糖(2hBG)、胰岛素水平,同时对STZ所致糖尿病小鼠进行胰腺病理组织学检查。结果:克糖特对正常小鼠血糖水平无影响,能够拮抗肾上腺素诱导的小鼠高血糖,显著降低STZ模型小鼠空腹血糖(P<0·05～0·01,与模型组比较降糖率可达24·39%)及2hBG(P<0·05),明显提高胰岛素水平(P<0·05～0·01),保护胰岛β细胞。结论:克糖特对STZ引起的高血糖有较强的降糖作用。其作用机制可能与改善受损的胰岛细胞功能、促进胰岛素分泌有关。
Objective: To study the effects and mechanism of Ketangte (KTT) on the blood sugar level in diabetic mice. Methods: Diabetic mice induced by streptozotocin (STZ),i.g.,and adrenaline were divided into 5 groups,and the mice were treated (i.g.) with glybenzcyclamide (50 mg/kg) and three different doses of KTT,respectively,for 15 days. The levels of blood sugar were measured in the mice with experimental hyperglycemias induced by adrenalin and STZ 15 days after treatment of drugs. Insulin levels in the diabetic...
基金
广西自然科学基金项目(No.桂科自0447039)
关键词
糖尿病小鼠
肾上腺素
链脲霉素
降血糖
diabetic mice
adrenaline
streptozotocin
hypoglycemic effect
