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乌司他丁对心脏不停跳心内直视术机体免疫功能的影响 被引量：4

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摘要 目的:研究乌司他丁(UTI)对体外循环(CPB)心脏不停跳心内直视术所造成的机体免疫功能变化的影响。方法:将40例拟在体外循环下行心脏不停跳心内直视手术的患者随机分成对照组(C组)和UTI组(U组),其中C组20例,U组20例。U组给予UTI 100万U,C组给予同样容量的生理盐水。分别于麻醉后切皮前(T1);CPB 15min(T2);停机时(T3);停机15min(T4);停机30min(T5);术毕(T6);术后2h(T7)及术后24h(T8)各时点收集外周静脉血测定下列各指标水平:淋巴细胞(LY)计数、肿瘤坏死因子(TNF-α)、白细胞介素-2,白细胞介素-6(IL-2,IL-6)。结果:CPB心脏手术后两组TNF-αI、L-6水平均明显升高,在T4、T5时点U组TNF-α水平显著低于C组;U组的IL-6水平在T3~T7时显著低于C组。对照组的LY计数、IL-2水平呈现先升高后降低的趋势,术后24 h这两个指标均明显降低,而U组的这两个指标在术后24h仍与术前相当。结论:UTI能够改善体外循环心不停跳手术造成的全身炎症反应和免疫抑制,从而保护机体的多种重要脏器功能,减少感染的风险。
作者 雷宾峰 陈铭伍 冼磊 何巍 冯旭 周华富
机构地区 广西医科大学第一附属医院心胸外科
出处 《广西医学院学报》 北大核心 2008年第3期381-383,共3页
基金 广西自然科学基金资助(No.桂科自0447048)
关键词 乌司他丁 体外循环 心不停跳 免疫功能 全身炎症反应
分类号 R654.2 [医药卫生—外科学]
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参考文献10

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共引文献13

同被引文献17

  • 1郭巍,邹承伟,王安彪,杜亮,范全心,李红昕.西咪替丁对体外循环手术患者免疫功能的保护作用[J].中国胸心血管外科临床杂志,2007,14(2):97-100. 被引量：15
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引证文献4

二级引证文献12

广西医学院学报
2008年 第3期

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