与非门(NAND)的DNA计算模型

Constructing the NAND Gate Based on DNA Computin

近年来,随着DNA计算研究的深入,基于DNA的布尔电路的模拟成为其中一个热门的研究方向.分子信标是一种特殊的探针分子,广泛应用于各种生物技术的检测方面,具有结果稳定,特异性强的优点,本文提出了一种基于诱导"发夹"形式的DNA与非门模型,和已有的模型相比,该模型具有简单,可靠性更高且可以重复使用等优点.

The hairpin structure of DNA molecules have been widely employed for a variety of biosensors and nanoscale molecular assembly applications.For example,the commonly known molecular beacons can report the presence of specific nucleic acids in homogeneous solutions with high accuracy.Recently,Smith et al.proposed to induce hairpin formation through the sequence- specific binding of a small-molecule ligand G-G mismatch.Not only did this make the control of the hairpin formation flexibly,but more important the i...