摘要
目的:明确双黄连粉针剂高剂量给药时有效成分绿原酸在大鼠体内的动态变化规律及其在唾液中的分布情况。方法:大鼠740 mg.kg-1静脉注射双黄连粉针后,反相高效液相色谱法测定绿原酸在血液、唾液中的浓度,采用Multi97进行统计处理,确定药动学参数。结果:绿原酸在大鼠体内符合二室模型分布,其主要药动学参数如下:t1/2=0.63 h,AUC=62.40μg.h-1.mL-1,Vc=3.58 L,CL=4.03 L.h-1。绿原酸的唾液浓度范围为:(0.42~9.88)μg.mL-1。结论:双黄连粉针高剂量给药时绿原酸呈非线性药动学消除过程,在唾液中的分布浓度较低。
Objective:To identify pharmacokinetics and salivary distribution of Chlorogenic acid after high-dose administration of Shuanghuanglian Injection in rats.Methods:Each rat was given a 740 mg·kg^(-1) dose of Shuanghuanglian Injection via the vein.RP-HPLC method was used to determine the concentrations of Chlorogenic acid in plasma and saliva.Pharmacokinetic model and parameters were analyzed by program Multi97.Results:Chlorogenic acid showed two compartment model in rats and the main parameters of pharmacokine...
出处
《中国实验方剂学杂志》
CAS
2008年第5期47-49,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
黑龙江省自然科学基金项目资助(D2007-22)
关键词
绿原酸
药动学
唾液分布
双黄连粉针
chlorogenic acid
pharmacokinetics
salivary distribution
Shuanghuanglian Injection
