摘要
目的:探讨黄芩苷对酒精性肝损伤大鼠的治疗作用及其机理。方法:用56°白酒每次按5mL·kg-1灌胃,2次/d。连续4周。第5周开始按5mL·kg-1灌胃白酒,1次/d,同时开始灌胃给予不同药物,1次/d,连续4周。结果:黄芩苷可以显著降低酒精性肝损伤大鼠血清和肝脏中丙氨酸氨基转换酶(ALT)、天门冬氨酸氨基转换酶(AST)活性,降低丙二醛(MDA)含量,提高超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性,降低酒精肝损伤大鼠血清中肿瘤坏死因子(TNF-α)含量。结论:黄芩苷对酒精性肝损伤大鼠具有保护作用,其作用机理可能与降低TNF-α和MDA含量有关。
Objective:To observe the effects of baicalin in chronic alcoholic live injury rats,and to study the terapeutic effects and mechanisms of baicalin on alcoholic live injury rats. Methods:The rats were given 56°(v/v) alcohol 5 mL·kg~ -1 twice daily for 28 days by ig,from the 5~ th week once daily for 4 weeks.In the same time the rats were given test agents according to the protocol for 28 days. Results: The experiments indicated that baicalin could obviously degraded the content of ALT,AST,MDA in rats serum an...
出处
《中国实验方剂学杂志》
CAS
2008年第6期58-60,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
吉林省科委项目(20050910)
关键词
黄芩苷
酒精性肝损伤
抗氧化作用
肿瘤坏死因子
baicalin
alcoholic liver injury
anti-oxidation
tumor necrosis factor（TNF-α）
