摘要
目的:观察益母草碱对大鼠急性心肌缺血损伤血管舒缩功能及抗氧化作用的影响。方法:垂体后叶素腹腔注射诱导大鼠急性心肌缺血,放射免疫法测定血浆及心肌内皮素(ET)含量,硝酸还原酶法测定血清和心肌一氧化氮(NO)含量,黄嘌呤氧化酶法测定血清和心肌超氧化物歧化酶(SOD)活力,硫代巴比妥酸法测定血清和心肌丙二醛(MDA)含量。结果:益母草碱在一定剂量范围内能升高血中和心肌NO水平(P<0.01),降低ET含量(P<0.01),增加SOD活力和降低MDA含量(P<0.01),且存在量效关系。结论:益母草碱具有对抗垂体后叶素性急性心肌缺血损伤的作用,其机制可能与平衡血管舒缩功能、抗脂质过氧化等有关。
Objective:To investigate the equilibrium of vasomotor function and the prevention of lipid peroxidation of leonurine(Leo) on pituitary(Pit)-induced acute myocardial ischemia injury in rats.Methods: Pit was administrated intraperitoneally to induce acute myocardial ischemia injury in rats.The concentration of endothelin(ET) in plasma and myocardium were measured by radio immunoassay.The level of nitric oxide(NO),the activity of superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in serum and my...
出处
《中国实验方剂学杂志》
CAS
2008年第7期34-37,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
安徽省教育厅自然科学基金项目(2003kj322)
