摘要
目的:探讨食管鳞癌组织中血管内皮生长因子C(vascular endothelial growth factorC,VEGF-C)、血管内皮生长因子D(vascular endothelial growth factor D,VEGF-D)的表达及与淋巴管生成和淋巴结转移的关系。方法:采用免疫组化法检测64例食管癌和14例癌旁正常食管黏膜中VEGF-C、VEGF-D和D2-40的表达,并分析其与临床病理诸因素的关系。结果:VEGF-C在淋巴结转移组和无淋巴结转移组的阳性率分别为73.08%(19/26)和34.21%(13/38),VEGF-D的阳性率分别为53.85%(14/26)和28.95%(11/38),差异有统计学意义,χ2值分别为9.328和4.021,P值分别为0.002和0.045。VEGF-C和VEGF-D之间的表达差异无统计学意义,χ2=1.641,P=0.20。癌组织和癌旁正常食管黏膜中D2-40阳性表达的淋巴管密度(lymphatic-vessel density,LVD)差异有统计学意义,P=0.000;VEGF-C阳性组与阴性组中D2-40阳性表达的LVD差异有统计学意义,P=0.010,而VEGF-D阳性组与阴性组中差异无统计学意义,P=0.543。结论:在食管癌中存在VEGF-C、VEGF-D的表达,VEGF-C通过增加癌周LVD促进肿瘤细胞的淋巴结转移,与VEGF-D各自参与淋巴结转移的作用。两者的表达预示淋巴结转移的增加,对食管癌预后估计有指导意义。
OBJECTIVE:To investigate the expressions of VEGF-C and VEGF-D and their correlations with lymphangiogenesis and lymph node metastasis of esophageal carcinoma.METHODS: Expressions of VEGF-C,VEGF-D and D2-40 in 64 cases of esophageal carcinoma and 14 cases of normal mucous away from cancer were detected by immunohistochemistry,and their correlations with clinical-pathological findings were analysed in patients.RESULTS: The positive rates of VEGF-C and VEGF-D in positive group and negative group of lymph node ...
出处
《中华肿瘤防治杂志》
CAS
2008年第12期917-920,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
食管肿瘤/病理学
血管内皮生长因子类
淋巴转移
免疫组织化学
esophageal neoplasms/pathology
vascular endothelial growth factors
lymphatic metastasis
immunohistochemistry
