放化疗联合治疗晚期食管癌的疗效观察

Therapeutic results of chemotherapy combined with radiotherapy in treatment of advanced esophageal cancer

为了探讨放化疗联合治疗晚期食管癌的疗效及毒副反应,回顾分析72例食管癌的随访资料,根据治疗方法不同分为放化疗联合组和单纯化疗组。结果放化联合组在肿瘤的消失、缩小方面明显高于单纯化疗组,两者差异有统计学意义,χ2=6.020,P=0.014。放化联合组1、3、5年的生存率明显高于单纯化疗组,两者差异有统计学意义,χ2值分别为9.758、4.431和4.546,P值分别为0.002、0.035和0.033。化疗最常见的不良反应为骨髓抑制和消化道反应,无Ⅲ度以上的不良反应和化疗相关死亡。放疗的不良反应主要为轻度骨髓抑制和乏力,但无中途停止和放疗相关死亡。初步研究结果提示,放化疗联合治疗晚期食管癌是目前较为理想的治疗方案。

The objective of this study was to explore the curative effect and side-effects of chemotherapy combined with radiotherapy in the treatment of advanced esophageal cancer.The data of seventy-two esophageal cancer patients were analyzed retrospectively.The patients were divided into two groups based on the different treatment methods.Group A received chemotherapy combined with radiotherapy,while group B received chemotherapy only.Chemotherapy combined with radiotherapy was more effective than chemotherapy,χ2=...