摘要
目的:探讨化疗对骨肉瘤αV、β3整合素表达的影响。方法:免疫组化法检测20例化疗前和31例化疗后骨肉瘤αV、β3整合素的表达情况。结果:αV、β3整合素在骨肉瘤细胞呈强阳性表达,而正常骨细胞均呈阴性表达,P=0.000;化疗后两者表达明显下降,P=0.000。秩和检验表明,化疗后αV整合素与肿瘤Enneking分期(P=0.014)、侵袭(P=0.007)、复发(P=0.021)明显相关;β3整合素表达与肿瘤复发明显相关,P=0.003。多因素分析显示,化疗后αV整合素表达水平是影响骨肉瘤侵袭独立因素,化疗后β3整合素是影响骨肉瘤复发独立因素。结论:αV、β3整合素可能成为骨肉瘤诊断的辅助指标;化疗可能通过下调骨肉瘤细胞αV、β3整合素表达而改变其相应的生物学活性;αV、β3整合素可能分别是影响骨肉瘤侵袭、复发的独立因素;αV、β3整合素可能作为判断骨肉瘤化疗预后的指标及化疗药物作用的靶分子。
OBJECTIVE:To investigate the influence of chemotherapy on the expressions of αV and β3 integrin in osteosarcoma.METHODS:Immunohistochemistry was used to compare the expressions of αV integrin and β3 Integrin in paraffin sections of 20 patients with non-treated osteosarcoma and those of 31 cases with chemotherapy-treated osteosarcoma.RESULTS:αV integrin and β3 Integrin expressed highly in non-pretreated osteosarcoma compared with the normal bone tissues(P=0.000),while chemotherapy reduced the expressions of ...
出处
《中华肿瘤防治杂志》
CAS
2008年第13期1018-1021,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
福建省泉州市科学基金(2006Z21)
