摘要
目的探讨阿托伐他汀对高血压合并高血脂患者炎症因子的影响。方法入选62例高血压合并高血脂患者,在常规降压治疗基础上加服阿托伐他汀20mg,睡前服用,1次/d。另入选58例单纯高血压患者和60例正常体检者分别为单纯高血压组和正常对照组。治疗时间12周。检测治疗前后3组研究对象血压、血脂、超敏C反应蛋白(hsCRP)、白介素-1(IL-1)、白介素-6(IL-6)等因素的变化。结果治疗前高血压合并高血脂组的血压和血脂明显高于正常对照组,经降脂和降压治疗后血压与血脂显著下降(P<0.05)。高血压合并高血脂组各炎症因子的水平明显高于单纯高血压组和正常对照组(P<0.05),阿托伐他汀治疗后各炎症因子的水平显著下降(P<0.05)。结论阿托伐他汀可改善高血压合并高血脂患者的炎症状态。
Objective To study the effects of atorvastatin on inflammatory factors in hypertensive patients with hyperlipidemia. Methods 62 hypertensive patients with hyperlipidemia received conventional antihypertensive therapy and the treatment of atorvastatin 20 mg(QN). 58 simple hypertensive patients and 60 normal subjects were served as control group.The changes of blood pressure、lipids、hsCRP、IL-1 and IL-6 were measured before and after 12 weeks treatmemt.Results The level of blood pressure and lipid in atorvastat...
出处
《中外医疗》
2008年第20期20-21,23,共3页
China & Foreign Medical Treatment
关键词
阿托伐他汀
高血压
高血脂
炎症因子
Atorvastatin
Hypertension
Hyperlipidemia
Inflammatory factors
