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乳腺癌与雌激素代谢酶相关基因的研究 被引量:1

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摘要 目的探讨乳腺癌与雌激素代谢酶基因之间的关系。方法采用病例-对照的研究方法,对30例女性正常人和32例女性乳腺癌患者进行对比研究。结果CYP1A1MspI基因与乳腺癌的危险性显著关联,而CYP17基因与乳腺癌的危险性无显著的相关性。结论CYP1A1MspI的杂合子和突变纯合子提高中国女性乳腺癌发病的易感性;而CYP17与乳腺癌之间可能存在较弱的关联。
作者 闫磊
出处 《中外医疗》 2008年第26期20-,共1页 China & Foreign Medical Treatment
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  • 1Boyapati SM,Shu XO,Gao YT,et al.Polymorphisms in CYP1A1and breast cancer carcinoma risk in a population-based case-control study of Chinese women[J].Cancer,2005,103(11):2228-2235.
  • 2Huang CS,Chern HD,Chang KJ,et al.Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP 17,CYP1A1,and COMT:a multigenic study on cancer susceptibility[J].Cancer Res,1999,59(19):4870-4875.
  • 3Zheng W,Me DW,Jin F,et al.Genetic polymorphism of cytochrome P450-1 B1 and risk of breast cancer[J].Cancer Epidemiol Biomarkers Prev,2000,9(2):147-150.
  • 4Shin A,Kang D,Nishio H,et al.Estrogen receptor alpha gene polymorphisms and breast cancer risk[J].Cancer Epidemiol Biomarkers Prev,2000,9(2):147-150.
  • 5Cai Q,Shu XO,Jin F,et al.Genetic polymorphisms in estrogen receptor alpha gene and risk of breast cancer:results from the Shanghai breast cancer study[J].Cancer Epidemiol Biomarkers Prev,2003,12(9):853-859.
  • 6Shen Yue Ping,Li Dekun,Zhang Zibao,et al.Joint effects of the CYP1A1 Mspl,ERal Pvu Ⅱ,and ERal Xba Ⅰ polymorphisms on the risk of breast cancer:results from a population based casecontrol study in Shanghai,China[J].Cancer Epidemiol Biomarker Prev,2006,12 (5):342-347.
  • 7Huang CS,Shen CY,Chang KJ,et al.Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan[J].Br J Cancer,1999,80:1838-1843.
  • 8Rothman KJ,Greenland S.Modem Epidemiology.2nd ed[M].Lippincott-Raven Publishers,1998,269-273.
  • 9Zhu BT,Conney AH.Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis[J].Cancer Res,1998,58:2269-2277.
  • 10Service RF.New role for estrogen in cancer[J].Science,1998,279:1631-1633.

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  • 1宋依凝,魏敏杰,金万宝.乳腺癌易感基因(BRCA)的生物学功能与临床意义[J].现代肿瘤医学,2008,16(11):1992-1994. 被引量:11
  • 2宋传贵,胡震,袁文涛,狄根红,沈镇宙,黄薇,邵志敏.上海地区早发性乳腺癌患者BRCA1和BRCA2基因突变分析[J].中华医学杂志,2005,85(43):3030-3034. 被引量:26
  • 3王晓稼,邵喜英.乳腺癌CYP19基因研究进展[J].实用肿瘤杂志,2007,22(2):178-182. 被引量:6
  • 4李佳圆,杨非,曾红艳,雷放鸣,李卉,陶苹.CYP1B1基因多态性与乳腺癌关系的病例-对照研究[J].卫生研究,2007,36(5):596-598. 被引量:3
  • 5Filippini SE, Vega A. Breast cancer genes: beyond BRCA1 and BRCA2[J]. Front Biosci (Landmark Ed), 2013, 18: 1358-1372.
  • 6Eisinger F, Sobol H, Serin D, et al. Hereditary breast cancer,circa 1750[J]. Lancet, 1998, 351(9112) : 1366.
  • 7Figueiredo JC, Brooks JD, Conti DV, et al. Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status [ J ]. Breast Cancer Res Treat, 2011, 127 (3) : 819-829.
  • 8Antoniou A, Pharoah PD, Narod S, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutationsde- tected in case Series unselected for family history : a combined anal- ysis of 22 studies [J]. Am J Hum Genet, 2003, 72 (5): 1117-1130.
  • 9M Ahmed, F Lalloo, A Howell, et al. Risks of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers[J]. Breast Canc- er Research, 2010, 12 ( suppl 1 ) : P14.
  • 10Spearcman AD, Sweet K, Zhou XP, et al. Clinically applicable medels to characterize BRCA1 and BRCA2 variants of uncertain significance [ J ]. J Clin Oncol, 2008, 26 (33) : 5393-5400.

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