期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PPARγ和MMP-7与胃癌及癌前病变的关系 被引量：7

Peroxisome proliferators activated receptor γ and matrix metallo protease 7 in gastric cancer and precancer
原文传递
导出
摘要 目的探讨过氧化物酶增殖物激活受体γ(PPARγ)与基质金属蛋白酶-7(MMP-7)与胃癌及癌前病变(轻度及重度异型增生)的关系。方法将胃镜活检及外科手术切除的胃组织标本分成4组,慢性胃炎组31例,轻度异型增生组25例,重度异型增生组27例,胃癌组28例,采用免疫组化检测PPARγ及MMP-7蛋白的表达,对结果进行统计分析。结果单独检测PPARγ与MMP-7,胃癌组的表达显著高于其他3组;联合检测PPARγ及MMP-7,两者在胃癌组及重度异型增生组的表达显著高于慢性胃炎组和轻度异型增生组。结论PPARγ和MMP-7是胃癌及胃癌前病变的重要标志,两者联合检测可对区分胃癌、重度异型增生与胃炎、轻度异型增生提供重要依据。 Objective To investigate the relationships of peroxisome proliferators activated receptor γ(PPARγ) and matrix metallo protease-7 ( MMP-7) with gastric cancer ( including low and high grade atypical hyperplasia). Methods One hundred and twenty gastric tissue specimens (four groups) were collected by gastroscopy or surgical operation, including 31 patients with chronic gastritis, 25 patients with low-grade atypical hyperplasia, 27 patients with high-grade atypical hyperplasia, and 28 patients with gastric can...
作者 刘鹏飞 刘顺英 钱建忠 江洁 夏惠治
机构地区 东南大学医学院附属江阴医院消化科 东南大学医学院附属中大医院消化科
出处 《中华消化内镜杂志》 2005年第3期171-173,共3页 Chinese Journal of Digestive Endoscopy
关键词 过氧化物酶增殖激活受体γ 基质金属蛋白酶-7 胃癌 胃炎 Peroxisome proliferators activated receptor γ Matrix metallo protease-7 Gastric cancer Gastritis
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献6

二级参考文献35

  • 1[1]Senota A, Itoh F, Yamamoto H, et al. Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer [J]. Clin Exp Metastasis, 1998, 16(4): 313～321
  • 2[2]Liu XP, Kawauchi S, Oga A, et al. Prognostic significance of matrix metalloproteinase-7(MMP-7) expression at the invasive front in gastric carcinoma [J]. Jpn J Cancer Res, 2002, 93 (3):291～295
  • 3[3]Adachi Y, Itoh F, Yammaoto H, et al. Matrix metalloproteinase matrilysin (MMP-7) participates in the progression of human gastric and esophageal cancers [J]. Int J Oncol, 1998,13:1031～1035
  • 4[4]Yamashita K, Azumano I, Mai M, et al. Expression and tissue localization of matrix metalloproteinase-7 (matrilysion) in human gastric carcinomas. Implications for vessel invasion and metastasis [J]. Int J Cancer(Pred Oncol), 1998, 79(2): 187～194
  • 5[5]Yammaoto H, Adachi Y, Itoh F, et al. Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma [J]. Cancer Res,1999, 59(14): 3313～3316
  • 6[6]Adachi Y, Yamamoto H, Itoh F, et al. Clinicopathologic and prognostic significance of matrilysin expression at the invasive front in human colorectal cancers [J]. Int J Cancer, 2001, 95(5): 290～294
  • 7[7]Miyazaki K, Hattori Y, Umenishi F, et al. Purification and characterization of extracellular matrix-dagrading metalloproteinase matrin(pump-1) secreted from human rectal carcinoma cell line [J]. Cancer Res, 1990, 50(24): 7758～7764
  • 8[8]Powell WC, Knox JD, Navre M, et al. Expression of metallopreteinase matrilysin in DU-145 cells increases the invasive potential in severe combined immunodeficient mice [J]. Cancer Res, 1993, 53(2): 417～422
  • 9[9]Kohn EC, Liotta LA. Molecular insight into cancer invasion:strategies for prevention and intervention [J]. Cancer Res,1995, 55(9): 1856～1862
  • 10[10]McDonell S, Wright JH, Gaire M, et al. Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes[J]. Biochem Soc Trans, 1994, 22(1-2): 58～63

共引文献123

同被引文献85

引证文献7

二级引证文献21

中华消化内镜杂志
2005年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部