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肺纤维化发生与防治机理的重要因素——细胞因子作用机制研究 被引量:15

Important factors concerning occurrence, prevention and treatment of pulmonary fibrosis——Research onto mechanism of cellular factors
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摘要   肺间质纤维化(Interstitial pulmonary fibrosis,简称肺纤维化或IPF)根据其病因可分为特发性和继发性两类.二者均以大量的成纤维细胞聚集、细胞外基质(Extracellular matrix,ECM)沉积并伴有炎性病变和损伤所致组织结构破坏为特征,是以弥漫性肺泡炎和肺泡结构紊乱最终导致肺间质纤维化为特征的疾病.肺纤维化的发病率和病死率都在逐年增高,且缺少特异性治疗.除了SARS可引起此病以外,其它很多肺系疾病都可以导致肺纤维化.……
出处 《中国中医药现代远程教育》 2004年第6期23-26,共4页 Chinese Medicine Modern Distance Education of China
关键词 肺纤维化 细胞因子 发病 防治 作用机制 pulmonary fibrosis cellular factor occurrence of disease prevention and treatment mechanism
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  • 1曾庆富,牛海艳.肺纤维化机制的研究进展[J].中华病理学杂志,2001,30(5):371-373. 被引量:43
  • 2[2]Rochester CL,Elias JA.Cytokine networking in interstitial and fibrotic lung disorders. Semin Respir Med,1993,14:389~416)
  • 3[3]Coker RK,Laurent GJ. Pulmonary fibrosis:cytokines in the balance. Eur Respir J,1998,11:1218~1221
  • 4[5]Liu JY,Brass DM,Hoyle GW,et al.TNF-α receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers. Am J Pathol,1998,153:1839~1847
  • 5[7]Hlackwell TS,Christman JW. The role of nuclear factor-κB in cytokine gene regulation. Am J Respir Cell Mol Bio1,1997,17:3~9
  • 6李永春,何冰,陈建,王海斌,章巍.核因子-κB在大鼠肺纤维化中的活性和表达及红霉素治疗对它的影响[J].北京医科大学学报,2000,32(1):14-17. 被引量:9
  • 7[9]Zhang XY,Shimura S,Masuda T,et al. Antisense oligonucleotides to NF-kappa B improve survival in bleomycin-induced pneumonia of the mouse. Am J Respir Crit Care Med ,2000,162:1561~1568
  • 8[10]Doerschur CM,Quinlan WM,Doyly NA,et al. The role of β-selection and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J lmmunol, 1996,157:4609~4614
  • 9[11]Hasegaua M,Sato S,Takehara K.Augmented production of chemokines (monocyte chemotatic protein-1 ,CP-1),macrophage inflammatory protein-1 alpha (MIP-α and MIP-1β)in patients with systemic sclerosis:MCP-1 and MIP-α maybe involved in the development of pulmonary fibrosis. Clin Exp Immunol, 1999,117(1): 159~165
  • 10蔡后荣,戴令娟,郑培德,孟凡青.肺纤维化大鼠肺组织转化生长因子β_1和前胶原基因的表达[J].中华医学杂志,2001,81(4):247-248. 被引量:23

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