肥大细胞的存活和凋亡

Survival and apoptosis of the mast cells

肥大细胞不仅参与过敏性炎症反应,而且在许多慢性炎症性疾病和天然免疫中也起着相当的作用。在正常情 况下肥大细胞在组织中保持恒定的数量,在哮喘及慢性炎症的损伤修复阶段可以观察到肥大细胞数量增加。本文就肥大细胞 存活和凋亡的因素调节机制作一综述。

Mast cells are recognized as the key cells of allergic inflammatory reaction but they are also implicated in the pathogenesis of a number of chronic inflammatory diseases and in native immunity. Mast cells keep a constant number in tissues in normal conditions, however increased numbers of mast cells are observed in the later phase of asthma and in both the inflammatory and the repair/remodeling stage. In this report, we discuss the possible mechanisms that regulate the survival and apoptosis of the mast cells.