硝基化和氧化相关酶类iNOS和COX-2与血液系统恶性肿瘤

Relationship between nitration and oxidation related enzymes iNOS,COX-2 and hematological malignancies

硝基化和氧化相关酶类的可诱导型一氧化氮合酶 (inducible nitric oxide synthase,i NOS)和环氧化酶 2型 (cyclooxy-genase- 2 ,COX- 2 )与肿瘤的相关性日益成为研究者关注的焦点。关于 i NOS和 COX- 2与血液系统恶性肿瘤的相关性存在两种不同的观点 ,它们的作用机制尚不清楚。针对 NOS、COX或两者的选择性抑制剂为血液系统恶性肿瘤的治疗提供了新的线索。

Inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) are nitration and oxidation related enzymes, and their correlations with tumors have been drawing more and more attention.There are 2 different viewpoints on the correlation between the 2 enzymes and hematological malignances,and their functioning mechanisms are still unclear.The selective inhibitors of NOS,COX,or the both may provide a new approach for the treatment of hematological malignancies.