TGF-β与原发性开角型青光眼

Transforming growth factor-β and primary open-angle glaucoma

TGF-β作为一种多功能细胞因子,具有多种生物学效应。它能调控小梁细胞外基质的合成与分泌及小梁细胞的收缩而影响房水流出阻力,促进青光眼滤过术后结膜瘢痕形成。TGF-β可能在原发性开角型青光眼(POAG)的发病机制中起重要作用,TGF-β抑制剂可能成为青光眼滤过术后抗结膜瘢痕化的辅助药物。

As a multifunctional cytokine,transforming growth factor-β(TGF-β) has many biological effects. It controls the extracellular matrix synthesis in trabecular meshwork cells and enhances the contractility of trabecular cells,which may increase the resistance of aqueous outflow. It can also promote the formation of the bleb scarring after filtration surgery. TGF-β is likely to play an important role in the pathogenesis and mechanism of primary open-angle glaucoma (POAG). The inhibitions of TGF-β may be used as an auxiliary agent for inhibiting the formation of the bleb scarring after filtration surgery.