摘要
1-Deoxynojirimycin (1,5-dideoxy-1,5-imino-D-glucitol, DNJ) and its derivatives have been found to have a number of biological activities, such as anti-HIV, anticancer, anti-diabetic, etc.[1] N-Hydroxylethyldeoxynojirimycin (Miglitol)has been used as a drug for treating diabetic. N-Butyl-1-deoxynojirimycin (NB-DNJ) has show potent anti-HIV-1 and HIV-2 activity without cytotoxicity.[2] Recently, NB-DNJ has been approved for clinical trials as a potential therapy for some glycosphingolipid (GSL) lysosomal storage diseases, which belong to a group of severe and fatal human diseases[3]Therefore, it is very significant to study N-substituted compounds of DNJ.……
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2004年第z1期1-,共1页
Chinese Journal of Organic Chemistry