HPLC Fingerprint and LC/MS/MS Identification of the Active Components in Radix Salviae Miltiorrhizae

Radix Salviae Miltiorrhizae (丹参, RSM), an important Chinese Materia Medica, is widely used for cardiovascular diseases in China. Phenolic compounds[1] and diterpenoids[2] which are the major constituents of RSM have been reported to protect myocardium against ischemia-induced derangement, protect neural cells against injuries caused by anoxia,inhibit platelet aggregation, reduce hepatic fibrosis and depress the activities of HIV-1.[3] For the purposes of establishing quality standard of RSM and studying the relationship between the pharmacological activities and quantities of constituents, we conducted studies on HPLC fingerprint and LC-MS-MS identification of the active constituents of RSM.……