西安市食管癌危险因素的Meta分析

Meta-analysis of risk factors of esophageal cancer in Xi’an

目的 :探讨西安市食管癌发生的危险因素 .方法 :应用Meta分析方法对食管癌危险因素病例对照研究的文献进行综合评价 .结果 :纳入本次Meta分析的 5篇研究文献中 ,累计食管癌病例 84 0例 ,对照 10 84例 ;有显著性意义的因素为吸烟 (男性 )、饮酒、食用酸菜、吃新鲜蔬菜和食管癌家族史 ,OR合并 分别为 2 .6 3(2 .0 1～ 3.4 3) ,1.74 (1.2 1～ 2 .5 1) ,1.2 7(1.0 3～ 1.5 6 ) ,0 .4 6 (0 .35～ 0 .6 1)和 3.75 (2 .30～ 6 .11) ,各OR合并 显著性检验结果P <0 .0 5 .吸烟的剂量效应分析显示 ,吸烟量 <2 0支 日、≥ 2 0支 日的OR合并 分别为 2 .2 1和 2 .5 4 ,具有剂量效应关系 .未发现喜食热烫饮食、喝茶与食管癌发生的关系 .结论 :吸烟 (男性 )、饮酒、食用酸菜和食管癌家族史是西安市食管癌发生的危险因素 ,而吃新鲜蔬菜是食管癌的保护因素 .

AIM: To investigate the risk factors of esophageal cancer (EC) in Xi’an. METHODS: We reviewed data of case-control studies on risk factors of EC in Xi’an and performed a meta-analysis. RESULTS: Five case-control studies were chosen for our detailed review, and 840 EC cases and 1084 controls were analyzed in the five studies about EC in Xi’an. Our meta-analysis of risk factors for EC showed that significant factors of EC were tobacco smoking (male), alcohol drinking, intake of pickled vegetables, intake of fresh vegetables and family history of EC. The pooled OR values were 2.63(2.01-3.43), 1.74(1.21- 2.51) , 1.27(1.03-1.56), 0.46(0.35-0.61) and 3.75 (2.30- 6.11) respectively (P<0.05). Dose-effect analysis of tobacco smoking showed that the pooled OR for smoking dosage<20 per day and ≥20 per day was 2.21 and 2.54,respectively. No relations were found between hot diet, tea drinking and EC in Xi’an. CONCLUSION: The risk factors of EC in Xi’an are tobacco smoking (male), alcohol drinking, intake of pickled vegetables, and family history of EC, while intake of fresh vegetables is a protective factor.