期刊文献+

他汀类药物的抗高血压和改善心室重构作用 被引量:3

下载PDF
导出
摘要 他汀类药物的调脂外作用已愈来愈受到临床关注。众多临床和基础实验研究证明 ,他汀类药物有直接和间接的抗高血压和改善心室重构作用。他汀类药物通过对血管内皮功能、G蛋白、胰岛素抵抗、血管紧张素受体、血管紧张素转换酶活性和活性氧的影响 ,从而拮抗高血压和改善心室重构。
作者 王安才 成蓓
出处 《中国动脉硬化杂志》 CAS CSCD 2004年第6期737-739,742,共4页 Chinese Journal of Arteriosclerosis
  • 相关文献

参考文献29

  • 1[1]Wassmann S, Laufs U, Baumer AT, Muller K, Konkol C, San er H, et al. Inhibition of geranvlgeranylation reduces angiotensin Ⅱ -mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Racl GTPase. MolPharmacol, 2001,59(3):646-654
  • 2王安才,成蓓.强化调脂治疗 加强冠心病防治[J].皖南医学院学报,2002,21(1):1-3. 被引量:7
  • 3秦晋梅,李建军.他汀类药物的抗炎作用[J].中国动脉硬化杂志,2004,12(3):363-366. 被引量:42
  • 4覃军,李爱民,何作云.他汀类药物对血管平滑肌细胞的直接作用及其意义[J].中国动脉硬化杂志,2000,8(4):373-375. 被引量:17
  • 5[5]Sung BH, Izzo JL, Wilson MF. Effects of cholesterol reduction on BP response to mental stress in patients with high cholesterol. Am J Hypertens, 1997, 10:592-599
  • 6[6]Abetel G, Poget PN, Bonnabry JP. Hypotensive effect of an inhibitor of cholesterol synthesis (fluvastatin). A Pilot Study. Schweiz Med Wochenschr, 1998,128:272-277
  • 7[7]Borghi C, Gaddi A, Dormi A, Veronesi M, AmbrosioniE. Improved blood pressue control in hypertensive patients teated with statins. J Am Coll Cardiol,2001, 37 (Supple A): 233A-234A
  • 8[8]Glorioso N, Troffa C, Filigheddu F, Dettori E, Soro A, Parpaglia PP, et al.Effect of the HMG-COA reductase inhibitors on blood pressure in patients with essential hypertension and primary hypercholesterolemia. Hypertension, 1999, 34(6): 1 281-286
  • 9[9]Tonolo G, Melis MG,Formato MF, Angius A, Carhoni P, Brizzi M,et al. Additive effects of simvastatin beyond its effects on LDL cholesterol in hypertensive type 2 diabetetic patients. Eur J Clin Invest, 2000, 30(11): 980-987
  • 10[10]Velussi M, Cermigo AM, Tortul C. Atorvastatin for the management of type-2diabetic patients with dyslipidemia. A mid-term(9-month) treatment experience.Diabetes Nutr Metab, 1999, 12 (5): 407-412

二级参考文献79

  • 1杨裕国,林东平,盛宏光,姚丕颖.降脂药物── 必降脂对糖代谢的影响[J].中华内分泌代谢杂志,1998,14(2):103-105. 被引量:29
  • 2李光伟 潘孝仁.检测人群胰岛敏感性的一项新指数[J].中华内科杂志,1993,32:656-656.
  • 3Simes J, Furberg CD, Braunwald E, Davis BR, Ford I, Tonkin A, et al.Effects of pravastatin on mortality in patients with and without coronary heart disease across a broad range of cholesterol levels.The Prospective Pravastatin Pooling project.Eur Heart J, 2002, 23 (3):207-215
  • 4Scandinavian Simvastatin Survival Study Group.Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease:the Scandinavian Simvastatin Survival Study (4S).Lancet, 1994, 344:1 383-389
  • 5Downs JR, Clearfield M, Weis S, Whitney E, Shapiro DR, Beere PA, et al.Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels:results of AFCAPS/TexCAPS.Air Force/Texas Coronary Atherosclerosis Prevention Study.J Am Med Assoc, 1998, 279 (20):1 615-622
  • 6Plutzky J, Ridker PM.Statins for Stroke:The Second Story? Circulation, 2002, 103 (3):348-350
  • 7Kobashigawa JA, Katznelson S, Laks H, Johnson JA, Yeatman L, Wang XM, et al.Effect of pravastatin on outcomes after cardiac transplantation.N Engl J Med, 1995, 333 (10):621-627
  • 8Wenke K, Meiser B, Thiery J, Nagel D, Scheidt WV, Steinbeck G, et al.Simvastatin reduces graft vessel disease and mortality after heart transplantation.Circulation, 1997, 96 (5):1 398-402
  • 9Strandberg TE, Vanhanen H, Tikkanen MJ.Effect of statins on C-reactive protein with coronary artery disease.Lancet, 1999, 353(9147):118-119
  • 10Rider PM, Rifai N, Pfeffer M, Sacks F, Braunwald E.For the cholesterol and recurrent event (CARE) investigators.Long-term effects of pravastatin on plasma concentration of C-reactive protein.Circulation, 1999, 100 (3):230-235

共引文献72

同被引文献32

引证文献3

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部