TGF-β_1在神经精神疾病患者血清中的含量变化及分析

The Content Change and Analysis of TGF-β_1 in Serum of Patients with Neuropsychosis

目的 探讨转化生长因子 β1在神经精神疾病的病因与发病机制中的作用。 方法 用双抗体夹心ELISA法检测 16例精神分裂症患者、3 2例阿尔茨海默病患者血清TGF -β1含量 ,两者加以比较 ,并以 2 0例正常人血清作为对照。 结果 精神分裂症与阿尔茨海默病两组间TGF -β1含量接近 ,两组间无显著性差异。两组TGF -β1含量均明显低于正常组 ,与正常组间存在显著性差异。 结论 TGF -β1可能通过影响细胞的增殖分化、抗原表达及免疫抑制、细胞毒等作用 ,参与神经精神疾病的发生。

Objectives To study the path physiological mechanisms of transforming growth factor-β 1 (TGF-β 1) in Alzheimer’s Disease and Schizophrenia. Methods By enzyme-linked immuno-sorbent assay ( ELISA),the study objects were 32 Alzheimer’s Disease patients,16 Schizophrenic patients and 20 healthy controls whose serum content of TGF-β 1 were tested and compared with each other. Results The serum content of TGF-β 1 is significantly lower in both Schizophrenic patients and Alzheimer's Disease patients,than in healthy controls,and there was no significant differences between Schizophrenic patients and Alzheimer's Disease patients. Conclusions TGF-β 1 may be concerned with the occurrence and progress of Alzheimer’s Disease and Schizophrenia .